Fig. 8

Microglia Ager deletion in male SOD1^G93A mice reduces the accumulation of disease-associated microglia at end-stage. a Representative images of CLEC7A staining in the lumbar spinal cord ventral horn of the indicated mouse groups. Scale bar: 50 μm. b Quantification of CLEC7A⁺ area. c Quantification of CLEC7A⁺ DAPI⁺ cell number. Mean ± SD. N = 7 SOD1^G93A Ager^fl/fl Cx3cr1^Cre/+ mice and N = 9 SOD1^G93A Ager^+/+ Cx3cr1^Cre/+ mice. Independent two sample two-sided t test. In b, **p < 0.0048. In c, *p = 0.0154