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Table 1 The possible factors of EG damage in TBI coagulopathy

From: Endothelial glycocalyx in traumatic brain injury associated coagulopathy: potential mechanisms and impact

Factors

Types

Natriuretic peptide

ANP, BNP, CNP

Catecholamine

NE, Epi

Inflammatory mediators

TNF-α, IL-1β, IL-6, IL-8, IL-10

Angiopoietin

Ang-2

Chemotactic factors

fMLP

Reactive species

ROS, RNS

Histone deacetylase

HDAC

Extracellular proteases

MMP-1, MMP-2, MMP-7, MMP-9, MMP-14, MMP-16,

ADAM-10, ADAM-15, ADAM-17

ADAMTS-1, ADAMTS-4

Heparanase, hyaluronidase, thrombin, plasmin, elastase, lysosomal cathepsin B, tryptase β

  1. EG endothelial glycocalyx, TBI traumatic brain injury, ANP atrial natriuretic peptide, BNP brain natriuretic peptide, NE norepinephrine, Epi epinephrine, TNF tumor necrosis factor, IL interleukin, Ang angiopoietin, fMLP N-formylmethionyl-leucyl-phenylalanine, ROS reactive oxygen species, RNS reactive nitrogen species, HDAC histone deacetylase, MMP matrix metalloproteinase, ADAM a disintegrins and metalloproteinase, ADAMT a disintegrin and metalloproteinase with thrombospondin motif
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Journal of Neuroinflammation

ISSN: 1742-2094