Fig. 7

Graphical abstract. In wild-type mice, the Iba-1⁺ myeloid cells including the microglia and macrophages express high levels of PGRN in response to acute inflammation. PGRN regulates the lysosomal function and activation in Iba-1⁺ myeloid cells. However, in PGRN deficient mice, the reduced levels of PGRN lead to abnormal activation of the lysosomes in the Iba-1⁺ myeloid cells. Lysosome-activated myeloid cells express proangiogenic and proinflammatory factors and promote the formation of CNV and vascular permeability