Fig. 5

NLRP3 inhibition decreases delayed cerebral vasospasm after SAH. A Representative images of vessel-casted brains of sham + vehicle (left), SAH + vehicle (middle), and SAH + MCC950 (right) groups 5 days after SAH. The internal carotid artery (ICA), middle cerebral artery (MCA), and anterior cerebral artery (ACA) are identified in sham image. Arrows indicate areas of significant vasospasm, scale bars = 100μm. B Middle cerebral artery measurements normalized to sham group. Data presented as mean ± SEM, n = 7–9 per group, *** p < 0.001 compared to sham surgery group by Kruskal-Wallis test with Dunn’s multiple comparison test. C Composite neurological evaluation score, p > 0.05 at all timepoints and across all groups by two-way ANOVA. D Prevalence of right turns in the corner test, * p < 0.05, ** p < 0.01 vs sham + vehicle group, # p < 0.05 vs SAH + vehicle group by two-way ANOVA with Tukey’s multiple comparison test