Fig. 12

PAK4 and KDM6B K.O CRISPR abolished the beneficial effects of GW9508 at 24 h after GMH. a, b The representative bands and quantification of GPR40, PAK4, p-PAK4, CREB, p-CREB, KDM6B, IL-1β, TNF-α, CD206, and IL-10. Data was represented as mean ± SD (n = 6 per group). One-way ANOVA was used followed by Tukey’s HSD post hoc test and Holm-Bonferroni correction. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. Sham group; ^@p < 0.05, ^@@p < 0.01 vs. GMH + vehicle group; ^&p < 0.05, ^&&p < 0.01 and ^&&&p < 0.001 vs. GMH + GW9508; ^#p < 0.05 and ^###p < 0.001 vs. GMH + GW9508 + scramble CRISPR group; ^$p < 0.05 vs. GMH + GW9508 + PAK4 K.O CRISPR group. Vehicle, 10% dimethyl sulfide