Fig. 3

Il10 deficiency significantly enhances p38 MAPK activation after LPS injection. WB of Hp homogenates from Non-Tg or Il10^−/− mice described above. A Levels of (activated) phospho-p38 MAPK relative to (total) p38 MAPK; GAPDH protein loading control. Each lane represents an individual mouse sample. B, C Quantification of immunoreactive bands as ratio of phospho-p38 over total-p38 (B) and total-p38 relative to GAPDH (B). Data shown are mean ± SEM of IDV ratio; * p < 0.05; ** p < 0.01; *** p < 0.001; two-way ANOVA with Sidak’s multiple comparison test; n = 6–7 mice/group