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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

Fig. 4

TLR2 deficiency on astrocytes abolished the decreased CSPGs deposition and upregulated astrocytes induced by SCDEs treatment. a Representative images of immunofluorescent analysis of CS56 (red), GFAP (green), and DAPI (blue) in TLR2f/f sham group, TLR2f/f group, TLR2f/f with SCDEs treatment group and TLR2−/−group at 2 weeks after SCI. Scale bars = 200 μm. Right images are high-resolution versions of the boxed regions in the left images, scale bars = 50 µm. bd Quantitative analysis of CSPGs area and the intensity value of CS56 and GFAP (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 6). e Representative images of immunofluorescent analysis of TLR2 (red), GFAP (green), and DAPI (blue) in TLR2f/f and TLR2−/− mice at 2 weeks after SCI. Scale bars = 20 μm. f Quantitative analysis of TLR2-positive astrocytes **P < 0.01, n = 6)

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