Fig. 2
Phenotypic changes in ADAR1K999N mice. A As shown at 3.5 weeks of age, the K999N mice are smaller with no gross structural abnormalities. B The difference in body weight between wild type and mutant mice increases over time, n = 15, 12 for control at 2.5 and 4 weeks, n = 8, 11 for K999N group at 2.5 and 4 weeks. p = 0.004 for 2.5 weeks and p = 0.001 for 4 weeks. C Although AGS patients can exhibit chilblain-like dermatologic manifestations in the ear, hands, and feet, no gross changes in mouse paws were evident in mutant mice. D Liver enzyme levels in control (n = 5, black) versus mutant (n = 7, red) mice for ALT, AST, and level for T. Bilirubin were not different, p = 0.066 (ALT), 0.404 (AST), and 1.0 (T. Bilirubin). The Wilcoxon rank-sum test was used to determine the statistical difference for the analysis in B and D