Fig. 7

HFD effect on BBB integrity in the striatum of sham, moderate, and severe lesion groups. A Confocal images showing plasma protein leakage (green) (fibrinogen left panel and IgG right panel) in sham, moderate, and severe lesion groups fed with either CTRL diet or HFD. B, C Corresponding quantification of extravascular fibrinogen and IgG, respectively. Data are expressed in sqrt % of leakage fraction area of the total image area. Sham (CTRL diet: n = 5, HFD: n = 4), moderate lesion mice (CTRL diet: n = 3, HFD: n = 3), and severe lesion mice (CTRL diet: n = 6, HFD: n = 4). Two-way ANOVA: *p < 0.05, **p < 0.01. Scale bar 50 μm. IgG immunoglobulin G