Fig. 5

Acute anti-inflammatory after UVN treatment exacerbates vestibular syndrome intensity and postural instability during vestibulo-spinal reflex after UVN. A Illustration of the assessment grid used to conduct the qualitative analysis. B Results representing the progression of the qualitative score along post-operative time for each group. C Pictures of the support surface of a representative animal at d3 for each group. For each rat, a measurement was taken during the preoperative time to serve as baseline so that each rat acts as its own control. Data were normalized according to the baseline for every time-point. D Results representing the changes of the support surface measured after tail suspension test (TST), reflecting the effectiveness of the vestibulospinal reflex along post-operative time for each group. A red box is applied on the curve to illustrate the acute time window of the vestibular syndrome (d1 to d3) where the treatments were administrated daily. Each data point represents the mean for each group with error bars representing SEM. *p < 0.05; **p < 0.01; ***p < 0.001, 2 two-way ANOVA, post hoc Tukey: the sham and UVN + placebo comparison is indicated by a blue*; the sham and UVN + met comparison is indicated by a green*; and the UVN + placebo and UVN + met comparison is indicated by a red*