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Table 1 Patient demographics, comparing CLEAR III cohort with cohort having at least 3 CSF differential cell counts available

From: CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

  Total CLEAR III Cohort Cohort with ≥3 CSF differentials
Alteplase (n=249) Saline (n=251) Alteplase (n=139) Saline (n=153)
Age (years) 59 (51–66) 59 (51–67) 57 (46–63) 58 (51–66)
Women 105 (42%) 117 (47%) 63 (45%) 71 (46%)
Race
 White 144 (58%) 161 (64%) 74 (53%) 87 (57%)
 Black 92 (37%) 78 (31%) 59 (42%) 58 (38%)
 Native American 0 1 (<1%) 0 0
 Other 13 (5%) 11 (4%) 6 (4%) 8 (5%)
 Ethnicity: Hispanic 28 (11%) 32 (13%) 15 (11%) 17 (11%)
Baseline variables
 Tobacco use 73 (29%) 59 (24%) 40 (29%) 41(27%)
 Cocaine 12 (5%) 18 (7%) 7 (5%) 12 (8%)
 Anticoagulation 20 (8%) 29 (12%) 15 (11%) 20 (13%)
 Hypertension 168 (67%) 202 (80%) 90 (65%) 122 (80%)
 Hyperlipidemia 240 (96%) 245 (98%) 132 (95%) 151 (99%)
 Antiplatelet use 56 (22%) 72 (29%) 28 (20%) 38 (25%)
 Mean arterial pressure 96 (86–106) 94 (86–104) 96 (88–108) 95 (87–105)
 Glasgow Coma Scale 10 (7–13) 9 (7–12) 10 (7–13) 10 (7–13)
 NIH Stroke Scale 19 (11–32) 20 (11–35) 18 (9–32) 19 (10–33)
Stability CT
 IVH volume (mL) 21.2 (12.7–34.2) 22.4 (12.7–39.1) 21.3 (13.7–35.3) 24.8 (16.4–39.6)
 ICH volume (mL) 8.3 (2.9–15.2) 7.2 (2.3–14.7) 8.3 (2.8–15.2) 7.7 (2.0–14.2)
Index clot location
 Thalamus 149 (60%) 144 (57%) 75 (54%) 83 (54%)
 Primary IVH 19 (8%) 27 (11%) 17 (12%) 16 (10%)
Time, hours since ICH
 Hospital arrival 1.5 (0.8–3.3) 1.5 (0.8–3.6) 1.5 (0.8–3.3) 1.6 (0.8–3.7)
 First CT 2.3 (1.3–4.6) 2.3 (1.4–5.2) 2.3 (1.3–4.7) 2.4 (1.4–5.6)
 First EVD 7.1 (4.5–11.9) 7.9 (5.1–12.0) 6.8 (4.5–10.6) 7.8 (5.1–11.0)
 Stability CT 43.1 (25.4–58.8) 44.0 (28.2–57.0) 43.6 (23.9–58.6) 43.8 (28.1–55.5)
 Randomization 51.8 (36.4–65.8) 52.2 (41.2–66.8) 52.0 (35.9–66.3) 52.0 (40.9–66.8)
  1. Data are median (interquartile range) or numbers (%). CSF indicates cerebrospinal fluid; CT, computed tomography; EVD, external ventricular drain; ICH, intracerebral hemorrhage; and IVH, intraventricular hemorrhage