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Table 1 Patient demographics, comparing CLEAR III cohort with cohort having at least 3 CSF differential cell counts available

From: CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

 

Total CLEAR III Cohort

Cohort with ≥3 CSF differentials

Alteplase (n=249)

Saline (n=251)

Alteplase (n=139)

Saline (n=153)

Age (years)

59 (51–66)

59 (51–67)

57 (46–63)

58 (51–66)

Women

105 (42%)

117 (47%)

63 (45%)

71 (46%)

Race

 White

144 (58%)

161 (64%)

74 (53%)

87 (57%)

 Black

92 (37%)

78 (31%)

59 (42%)

58 (38%)

 Native American

0

1 (<1%)

0

0

 Other

13 (5%)

11 (4%)

6 (4%)

8 (5%)

 Ethnicity: Hispanic

28 (11%)

32 (13%)

15 (11%)

17 (11%)

Baseline variables

 Tobacco use

73 (29%)

59 (24%)

40 (29%)

41(27%)

 Cocaine

12 (5%)

18 (7%)

7 (5%)

12 (8%)

 Anticoagulation

20 (8%)

29 (12%)

15 (11%)

20 (13%)

 Hypertension

168 (67%)

202 (80%)

90 (65%)

122 (80%)

 Hyperlipidemia

240 (96%)

245 (98%)

132 (95%)

151 (99%)

 Antiplatelet use

56 (22%)

72 (29%)

28 (20%)

38 (25%)

 Mean arterial pressure

96 (86–106)

94 (86–104)

96 (88–108)

95 (87–105)

 Glasgow Coma Scale

10 (7–13)

9 (7–12)

10 (7–13)

10 (7–13)

 NIH Stroke Scale

19 (11–32)

20 (11–35)

18 (9–32)

19 (10–33)

Stability CT

 IVH volume (mL)

21.2 (12.7–34.2)

22.4 (12.7–39.1)

21.3 (13.7–35.3)

24.8 (16.4–39.6)

 ICH volume (mL)

8.3 (2.9–15.2)

7.2 (2.3–14.7)

8.3 (2.8–15.2)

7.7 (2.0–14.2)

Index clot location

 Thalamus

149 (60%)

144 (57%)

75 (54%)

83 (54%)

 Primary IVH

19 (8%)

27 (11%)

17 (12%)

16 (10%)

Time, hours since ICH

 Hospital arrival

1.5 (0.8–3.3)

1.5 (0.8–3.6)

1.5 (0.8–3.3)

1.6 (0.8–3.7)

 First CT

2.3 (1.3–4.6)

2.3 (1.4–5.2)

2.3 (1.3–4.7)

2.4 (1.4–5.6)

 First EVD

7.1 (4.5–11.9)

7.9 (5.1–12.0)

6.8 (4.5–10.6)

7.8 (5.1–11.0)

 Stability CT

43.1 (25.4–58.8)

44.0 (28.2–57.0)

43.6 (23.9–58.6)

43.8 (28.1–55.5)

 Randomization

51.8 (36.4–65.8)

52.2 (41.2–66.8)

52.0 (35.9–66.3)

52.0 (40.9–66.8)

  1. Data are median (interquartile range) or numbers (%). CSF indicates cerebrospinal fluid; CT, computed tomography; EVD, external ventricular drain; ICH, intracerebral hemorrhage; and IVH, intraventricular hemorrhage