| Total CLEAR III Cohort | Cohort with ≥3 CSF differentials | ||
---|---|---|---|---|
Alteplase (n=249) | Saline (n=251) | Alteplase (n=139) | Saline (n=153) | |
Age (years) | 59 (51–66) | 59 (51–67) | 57 (46–63) | 58 (51–66) |
Women | 105 (42%) | 117 (47%) | 63 (45%) | 71 (46%) |
Race | ||||
 White | 144 (58%) | 161 (64%) | 74 (53%) | 87 (57%) |
 Black | 92 (37%) | 78 (31%) | 59 (42%) | 58 (38%) |
 Native American | 0 | 1 (<1%) | 0 | 0 |
 Other | 13 (5%) | 11 (4%) | 6 (4%) | 8 (5%) |
 Ethnicity: Hispanic | 28 (11%) | 32 (13%) | 15 (11%) | 17 (11%) |
Baseline variables | ||||
 Tobacco use | 73 (29%) | 59 (24%) | 40 (29%) | 41(27%) |
 Cocaine | 12 (5%) | 18 (7%) | 7 (5%) | 12 (8%) |
 Anticoagulation | 20 (8%) | 29 (12%) | 15 (11%) | 20 (13%) |
 Hypertension | 168 (67%) | 202 (80%) | 90 (65%) | 122 (80%) |
 Hyperlipidemia | 240 (96%) | 245 (98%) | 132 (95%) | 151 (99%) |
 Antiplatelet use | 56 (22%) | 72 (29%) | 28 (20%) | 38 (25%) |
 Mean arterial pressure | 96 (86–106) | 94 (86–104) | 96 (88–108) | 95 (87–105) |
 Glasgow Coma Scale | 10 (7–13) | 9 (7–12) | 10 (7–13) | 10 (7–13) |
 NIH Stroke Scale | 19 (11–32) | 20 (11–35) | 18 (9–32) | 19 (10–33) |
Stability CT | ||||
 IVH volume (mL) | 21.2 (12.7–34.2) | 22.4 (12.7–39.1) | 21.3 (13.7–35.3) | 24.8 (16.4–39.6) |
 ICH volume (mL) | 8.3 (2.9–15.2) | 7.2 (2.3–14.7) | 8.3 (2.8–15.2) | 7.7 (2.0–14.2) |
Index clot location | ||||
 Thalamus | 149 (60%) | 144 (57%) | 75 (54%) | 83 (54%) |
 Primary IVH | 19 (8%) | 27 (11%) | 17 (12%) | 16 (10%) |
Time, hours since ICH | ||||
 Hospital arrival | 1.5 (0.8–3.3) | 1.5 (0.8–3.6) | 1.5 (0.8–3.3) | 1.6 (0.8–3.7) |
 First CT | 2.3 (1.3–4.6) | 2.3 (1.4–5.2) | 2.3 (1.3–4.7) | 2.4 (1.4–5.6) |
 First EVD | 7.1 (4.5–11.9) | 7.9 (5.1–12.0) | 6.8 (4.5–10.6) | 7.8 (5.1–11.0) |
 Stability CT | 43.1 (25.4–58.8) | 44.0 (28.2–57.0) | 43.6 (23.9–58.6) | 43.8 (28.1–55.5) |
 Randomization | 51.8 (36.4–65.8) | 52.2 (41.2–66.8) | 52.0 (35.9–66.3) | 52.0 (40.9–66.8) |