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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Fig. 1

RSL3 inhibits LPS-induced proinflammatory cytokine production of microglia and PMs. a qRT-PCR analysis of TNF, IL-6, and IL-1b mRNA levels in LPS (100 ng/ML)-stimulated PMs subjected to different doses of RSL3 treatment for 4 h. b ELISA of TNFα, IL-6, and IL-1β in supernatants of LPS-stimulated PMs subjected to different doses of RSL3 treatment for 8 h. c qRT-PCR analysis of TNF, IL-6, and IL-1b mRNA levels in LPS (100 ng/ML)-stimulated BV2 cells subjected to different doses of RSL3 treatment for 4 h. d ELISA of TNFα, IL-6, and IL-1β in supernatants of LPS-stimulated BV2 cells subjected to different doses of RSL3 treatment for 8 h. The data are means ± SD; for all panels, *P < 0.05, **P < 0.01, ***P < 0.001 by one-way-ANOVA analysis followed by Dunnett test. n.s., no significant. The data are combined from three independent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094