Fig. 1
From: Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis
BAY 11-7082 inhibits sevoflurane-induced NF-κB activation. Rat pups at PND 6 were randomly assigned to one of four treatment protocols: control + vehicle (Con group), control + BAY 11-7082 (Con + BAY group), sevoflurane + vehicle (Sev group), and sevoflurane + BAY 11-7082 (Sev + BAY group). BAY 11-7082 (20 mg/kg) or PBS (vehicle) was intraperitoneally administered to the pups 30 min before gas inhalation. Sevoflurane anesthesia was induced by placing the rat pups in an anesthetizing chamber delivering 3% sevoflurane for 2 h daily for three consecutive days. For the control condition, 30% O2 was delivered at the same flow rate. A, B Representative western blotting and quantitative analysis of the protein levels of IκBα, p-IκBα, and cytoplasmic and nuclear NF-κB from fresh hippocampal tissue homogenates obtained at PND 8. Values are presented as mean ± SEM (n = 6 rats/group). *p < 0.05 versus the Con group; #p < 0.05 versus the Sev group