Fig. 1

Pharmacological inhibition of NHE1 protein in BCAS mice improved their spatial working memory. a Experimental protocol. C57BL/6J mice underwent sham or BCAS surgery. BCAS mice received either saline vehicle (Veh) or HOE642 (0.3mg/kg/day) via intraperitoneal injection (i.p.) for 3–30 days or via mini-pump for 0-28 days. b Representative images of regional cerebral blood flow (rCBF). c PeriCam PSI analysis of rCBF. Data are presented as mean ± SD. n = 5–9/group. *p < 0.05, **p < 0.01, ***p < 0.001. d The percentage of spontaneous alternation and total entry in Y maze test. n = 8–9/group. *p < 0.05, ****p < 0.0001. e Open field test. Data are represented as mean ± SD. n = 8–9/group. *p < 0.05 vs. sham. ^#p < 0.05 vs. Veh