Table 2 Changes in gene expression in adult microglia exposed to TLR agonists for 10 h relative to unexposed adult microglia in medium alone

Ccl1

− 1.7

3.0E-01

− 4.6

7.3E-03

− 4.4

1.6E-02

Ccl11

− 1.2

8.5E-01

− 5.3

1.8E-02

− 5.2

3.1E-02

Ccl12

13.0

4.5E-03

− 2.0

2.4E-01

1.2

7.6E-01

Ccl17

76.1

6.8E-03

25.4

9.6E-04

4.7

3.6E-02

Ccl2

85.9

1.4E-04

2.6

7.3E-03

− 2.0

2.2E-01

Ccl20

330.2

3.5E-05

15.7

2.0E-03

− 3.3

2.1E-02

Ccl22

7.8

6.6E-02

1.6

6.3E-01

1.3

8.0E-01

Ccl24

− 2.0

1.9E-01

− 4.2

1.2E-02

− 3.6

2.9E-02

Ccl3

155.5

3.9E-04

22.2

4.1E-03

− 1.5

2.9E-01

Ccl4

48.8

1.7E-03

4.4

4.7E-02

− 1.6

2.7E-01

Ccl5

1671.6

6.9E-05

127.7

2.9E-04

− 1.3

7.9E-01

Ccl7

58.0

9.0E-04

2.7

1.7E-01

− 1.0

9.8E-01

Ccl8

4.3

1.2E-01

-1.2

8.1E-01

− 3.3

2.1E-02

Ccl9

24.3

1.2E-02

13.7

1.9E-02

− 1.1

8.8E-01

Ccr1

2.7

2.3E-02

1.6

2.6E-01

1.4

4.9E-01

Ccr10

− 2.3

1.0E-04

− 3.5

7.3E-03

− 3.3

2.1E-02

Ccr2

− 1.3

7.1E-01

− 1.6

5.7E-01

− 3.3

2.1E-02

Ccr4

− 2.0

3.6E-01

− 5.1

2.9E-02

− 3.3

7.9E-02

Ccr5

− 2.5

9.1E-02

− 4.5

7.1E-03

1.2

5.9E-01

Ccr6

− 1.2

8.3E-01

− 3.8

7.1E-03

− 3.2

1.2E-02

Ccr8

− 2.3

1.0E-04

− 3.5

7.3E-03

− 3.3

2.1E-02

Cd40lg

− 2.7

2.0E-03

− 3.9

7.7E-03

− 3.8

1.9E-02

Csf2

211.5

1.1E-03

8.9

6.8E-02

− 1.0

9.7E-01

Csf3

13,079.3

3.0E-05

553.8

1.8E-06

− 1.8

4.2E-01

Cxcl1

1,668.9

9.1E-06

160.9

1.2E-05

− 1.9

2.2E-01

Cxcl10

2,193.5

7.7E-05

10.7

3.4E-02

− 19.3

3.6E-02

Cxcl13

− 2.9

9.8E-03

− 4.4

1.2E-02

− 4.2

2.3E-02

Cxcl15

− 2.4

1.7E-01

− 6.1

3.3E-02

− 6.9

1.9E-02

Cxcl5

30.3

4.7E-05

2.1

1.4E-01

1.1

9.1E-01

Cxcl9

− 2.1

4.9E-03

− 3.5

7.3E-03

− 3.3

2.1E-02

Cxcr2

− 3.6

9.8E-02

− 6.0

4.8E-02

− 2.1

5.4E-01

Cxcr5

1.0

9.8E-01

− 9.6

2.1E-02

− 4.3

1.8E-01

Fasl

− 2.3

1.0E-04

− 3.5

7.3E-03

− 3.3

2.1E-02

Ifng

11.0

4.0E-02

1.2

8.7E-01

− 6.1

6.7E-02

Il11

7.2

3.3E-02

1.8

6.1E-01

− 1.7

6.5E-01

Il13

31.4

6.4E-04

− 1.3

8.2E-01

− 3.3

2.1E-02

Il15

16.1

3.1E-03

− 2.1

9.7E-02

− 1.8

1.5E-01

Il17a

− 2.2

1.8E-03

− 3.5

7.3E-03

− 3.4

2.1E-02

Il17b

− 1.8

7.1E-01

− 5.9

1.3E-01

− 9.6

3.0E-02

Il17f

− 1.5

1.4E-01

1.2

8.9E-01

− 3.3

1.9E-02

Il1a

595.2

2.9E-05

34.2

7.2E-05

− 1.4

3.9E-01

Il1b

5258.1

1.9E-05

248.9

1.1E-04

− 1.3

7.1E-01

Il1rn

52.8

9.3E-04

6.3

1.4E-02

− 1.5

2.7E-01

Il21

− 4.0

5.0E-02

− 6.0

3.3E-02

− 5.7

4.3E-02

Il27

1463.6

4.7E-06

5.8

3.6E-02

1.3

8.6E-01

Il2rb

− 1.4

6.2E-01

− 3.5

7.3E-03

− 3.3

2.1E-02

Il33

2.0

4.3E-01

− 3.5

7.3E-03

− 3.3

2.1E-02

Il4

− 1.7

1.8E-01

− 1.6

3.5E-01

− 3.3

2.1E-02

Il5

− 2.0

5.2E-01

− 6.7

5.4E-02

− 10.6

2.9E-02

Il5ra

− 2.2

2.5E-04

− 3.5

7.3E-03

− 1.8

1.6E-03

Nampt

4.6

1.1E-01

1.2

8.3E-01

− 4.8

2.7E-02

Spp1

− 3.7

3.6E-02

− 2.6

3.6E-01

− 3.2

1.1E-01

Tnf

3.5

5.5E-04

1.7

2.5E-02

− 1.0

6.7E-01

Tnfsf11

− 2.2

1.8E-02

− 3.1

1.0E-03

− 1.3

1.0E-01

Tnfsf4

89.9

1.0E-03

19.0

2.7E-03

1.5

4.0E-01