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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

Fig. 6

NAD+ and overexpression of Sirt1 reduced the generation of pro-inflammatory cytokines in hypoxia-challenged microglia. A Cell viability results of BV2 microglial cells exposed to 0 mM, 1 mM, 5 mM, and 10 mM NAD+ for 24 h. B Western blot for Sirt1 in BV2 microglia transfected with Sirt1 lentiviral particles. Data are expressed as mean ± SEM (n = 3), **P < 0.01 vs. control. C The mRNA expression of pro-inflammatory markers (IL-1β, IL-6, iNOS, TNF-α, and COX2) was assessed by qRT-PCR. Data are expressed as mean ± SEM (n = 3). *P < 0.05, **P < 0.01 vs. Hyp and Hyp+NC

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Journal of Neuroinflammation

ISSN: 1742-2094