Fig. 1

Kynurenine pathway in post-mortem brain PFC samples of subjects with chronic SZ and matched controls. IL-10 (A), IL-1ß (B), IL-4 (C) (ELISA); IDO1 (D), IDO2 (E), TDO (F), KATII (G), KMO (H) (western blot); KYNA (I) and QA (J) (ELISA) levels in PFC of SZ subjects (black squares) and matched controls (grey circles). B The densitometric data of the respective bands of interest are normalized with respect to β-actin (lower band). The blots are representative of all data analysed and have been cropped to improve the clarity and conciseness of the presentation. *p < 0.05; **p < 0.01; ***p < 0.001 vs. control (C). ^aStudent’s unpaired t-test or ^bMann-Whitney test. Data represent the mean ± standard error of the mean (N = 14 control and 15 SZ). IL-10, interleukin-10; IL-4, interleukin-4; IL-1β, interleukin 1 beta; IDO1, indoleamine 2,3-dioxygenase 1; IDO2, indoleamine 2,3-dioxygenase 2; TDO, tryptophan 2,3-dioxygenase 2; KMO, kynurenine monooxygenase; KATII, kynurenine aminotransferases II