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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH

Fig. 4

Pharmacological inhibition of the fusion of autophagosome and lysosome abolished the neuroprotective effect of NRBF2 against SAH at 24 h. A, B Quantification of neurological function with two different scoring systems at 24 h after SAH. n = 12. C Quantification of brain water content. n = 6. D–J Representative western blotting images and quantitative analyses of CHOP, Romo-1, TXNIP, NLRP3, TNF-α, and IL-1β expression at 24 h after SAH. n = 6. Data are represented as mean ± SD (C, E–J) or median (interquartile range) (A, B). *P < 0.05 versus sham group. #P < 0.05 versus SAH + NC-AAV group. &P < 0.05 versus SAH + NRBF2-AAV + vehicle group

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Journal of Neuroinflammation

ISSN: 1742-2094