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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury

Fig. 3

NLRP3 knockout significantly improved LTP amplitude without a significant reduction in IL-1β, IL-18 or TNF-α levels. A Slope changes in fEPSP in the prefrontal cortex at 4 weeks post-TBI. B NLRP3 knockout significantly improved LTP amplitude in the prefrontal cortex at 4 weeks post-TBI. Data represent the means ± SD (n = 9 slopes per group), unpaired t-test. ****p < 0.0001 compared to the WT group. CH ELISA results for IL-1β, IL-18 and TNF-α levels in hippocampal and prefrontal cortex tissue, 2-way ANOVA. Data represent the means ± SD (n = 3 per group). ns (p > 0.05) compared to the WT group. Each experiment was repeated three times

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