Fig. 1

Regulated protein in the cerebellum of GIFN39 mice are characteristic of an interferon-induced immune response. A Distribution of protein abundances (nonphosphopeptides; blue: reduced and red: increased; number of significantly altered proteins is indicated at the top) in GIFN39 vs WT cerebella and their relative abundance estimated by NSAF (grey: protein abundance below threshold). Data of cerebella from WT (n = 4) and GIFN39 (n = 4) mice were analyzed from two runs with n = 2 per genotype in each. B Top 20 pathways associated with the regulated proteins in the cerebellum of GIFN39 mice compared with WT mice, determined by IPA. The dashed line: P = 0.05