Fig. 3

Ang-(1–7)/MasR agonists rescue cognitive impairment in a VCID mice. A Discrimination ratio = (Time spent at new object- Time spent at familiar object)/ total exploration time. Heart failure (HF) mice were treated with saline PNA5 or Ang-(1–7) at two different concentrations of either 50ug/kg, (P50, A50) or 500ug/kg (P500, A500). ****p < 0.001 Control-Saline vs HF-Saline. *p < 0.05 HF-Saline vs HF-P50, HF-P500, HF-A500. Data are represented with mean and ± SE. Difference in groups were tested by ANOVA, Dunnett’s post, significance p < 0.05. B No significant differences are noted in total exploration time in the familiarization test for all treatment groups. Data are represented with mean and ± SE. Significancy were tested by ANOVA