Fig. 2
From: T lymphocyte senescence is attenuated in Parkinson’s disease
Senescent CD8+ lymphocytes in CMV-positive versus CMV-negative patients and controls. A Two-way ANOVA with Sidak’s multiple comparisons test showed a statistically significant main effect of CMV seropositivity, F(1,118) = 11.9, p < 0.001. Post hoc pairwise comparison revealed a significant increase in the absolute count of CD8+ CD28loCD57hi T lymphocytes in CMV-positive compared to CMV-negative controls (p = 0.026). There was no statistically significant difference between CMV-positive and CMV-negative PD patients (p = 0.260). B Two-way ANOVA with Sidak's multiple comparisons test showed a statistically significant main effect of CMV seropositivity F(1,118) = 26.16, p < 0.0001 and main effect of group F(1,118) = 7.382, p = 0.008. Post hoc pairwise comparison revealed a significant increase in the absolute count of CD8+ TEMRA cells in CMV-positive compared to CMV-negative controls (p < 0.001) and in CMV-positive compared to CMV-negative PD patients (p = 0.026) CMV: Cytomegalovirus, TEMRA: terminally differentiated effector memory cells re-expressing CD45RA. ***p < 0.001,*p < 0.05