Fig. 2

LPS induces anemia of inflammation in blood cells of both 5xFAD (two-hit) and nTg (single-hit—environmental) mice. Mice of both sexes were administered with LPS (0.5 mg/kg, intraperitoneal, weekly, ip) from 12 to 20 weeks of age. Mice were euthanized 24 h after the last LPS injection. A Effect of LPS on RBC, lymphocyte, monocyte, neutrophil and platelet counts in two-hit 5xFAD mice, compared to single-hit—genetic mice. B Effect of LPS on hemoglobin (HGB), % hematocrit (HCT) and distribution width of RBC (RDWc) and platelet (PDWc) in two-hit 5xFAD mice. C Effect of LPS on blood cell count in single-hit—environmental mice, compared to no-hit mice. B Effect of LPS on hemoglobin (HGB), % hematocrit (HCT) and cell distribution width in single-hit—environmental mice. Multiple unpaired t test with Bonferroni correction was applied between groups. P values were set to be significant at * ≤ 0.05, ** ≤ 0.01 and *** ≤ 0.001. Data are mean ± SEM