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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Fig. 10

Autophagy inhibition attenuated the effects of CXCR5 knockdown on microglial polarization and inflammatory cytokines production in LPS-treated microglial cultures. a–g Western blot and densitometry of LC3, Iba-1, CD86, and CD206, IL-1β, IL-6 and the ratio of LC3-II/LC3-I (n = 4 per group). *p < 0.05 vs. control; #p < 0.05 vs. LPS; &P < 0.05 vs. LPS + CXCR5 siRNA. CXCR5 C-X-C chemokine receptor type 5, GAPDH glyceraldehyde-3-phosphate dehydrogenase, Iba-1 ionized calcium binding adaptor molecule-1, IL-1β interleukin (IL)-1β, IL-6 interleukin (IL)-6, LC3 microtubule-associated protein 1 light chain 3, LPS lipopolysaccharide, 3-MA 3-methyladenine

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Journal of Neuroinflammation

ISSN: 1742-2094