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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-κB/STAT3 signaling pathway

Fig. 9

CXCR5 knockdown inhibited activation of p38MAPK-dependent NF-κB/STAT3 signaling in LPS-treated microglial cultures. a–d Western blot and densitometry of p-p38MAPK, p38MAPK, p-NF-κB, NF-κB, p-STAT3 and STAT3 and relevant ratios (n = 4 per group). *p < 0.05 vs. control; #p < 0.05 vs. LPS; &P < 0.05 vs. LPS + CXCR5 siRNA. GAPDH glyceraldehyde-3-phosphate dehydrogenase, LPS lipopolysaccharide, NF-κB nuclear factor kappa-B, p38MAPK p38 mitogen-activated protein kinase, p- phosphorylated, STAT3 signal transducer and activator of transcription

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Journal of Neuroinflammation

ISSN: 1742-2094