Fig. 3
From: Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection
UTI induces neuronal changes to the frontal cortex and hippocampus. a Representative regions of interest (ROIs) of measured brain regions, i.e., frontal cortex, and hippocampus. b, c Quantification of cleaved caspase-3 (CC3) in the frontal cortex and the hippocampus show significantly increased CC3 in the UTI group compared to the control group (n = 7–9). d Quantitative data show significant increase in c-Fos in frontal cortex area in the UTI group compared to the control group (n = 5–9). e, f Representative images of CC3 and c-Fos (both shown in green) in both the frontal cortex and hippocampus show increases in both markers in UTI mice compared to controls. Quantitative data are expressed in mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001