Fig. 7
From: Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
Anti-h ERMAP mAb increases the proportion and the function of macrophages. 3XTg-AD mice were injected with anti-ERMAP mAb, or control isotype Ab as in Fig. 3. Three and a half months later, the brain and the spleen were harvested. The brain was analyzed for the A, B percentage of CD45hiCD11b+ cells, C the expression of Ly6C by CD45hi or CD45lo cells, D the percentage of Ly6C+ in CD45hiCD11b+ cells, and E, F the expression of SRA1 by CD45hiCD11b+ cells. The splenocytes were analyzed for G, H the percentage of F4/80+ macrophages, and I, J the macrophages were analyzed for the ability to phagocytose HiLyte Fluor 647-Aβ42. The data are expressed as mean ± SD from one of three independent experiments with similar results (5–8 mice per group in each experiment). *P < 0.05 versus control Ab group