Table 1 Impact of HFD and UCMS on brain concentrations of monoamines and their metabolites
(pmoles/g tissue) | Controls | UCMS | HFD | HFD-UCMS | |
|---|---|---|---|---|---|
Hippocampus | [5-HT] | 2031.5 ± 189.9 | 1688.0 ± 163.3 | 1487.1 ± 141.6* | 1934.3 ± 280.2 |
[5-HIAA] | 2044.0 ± 146.6 | 2084.0 ± 124.4 | 2610.4 ± 477.8 | 2297.3 ± 177.4 | |
5-HIAA/5-HT | 1.1 ± 0.2 | 1.3 ± 0.2 | 1.6 ± 0.3 | 1.4 ± 0.2 | |
[DA] | 57.7 ± 6.9 | 69.0 ± 14.0 | 116.5 ± 34.3* | 171.2 ± 51.5* | |
[DOPAC] | 87.6 ± 11.7 | 77.5 ± 6.9 | 95.7 ± 13.6 | 120.2 ± 29.9 | |
[HVA] | ND | ND | ND | ND | |
DOPAC/DA | 1.5 ± 0.2 | 1.7 ± 0.4 | 1.1 ± 0.2 | 1.0 ± 0.2 | |
Cortex | [5-HT] | 1662.7 ± 83.4 | 1657.6 ± 80.7 | 1505.8 ± 75.8 | 1717.2 ± 95.9 |
[5-HIAA] | 1939.8 ± 178.4 | 1741.1 ± 169.7 | 1559.5 ± 199.2 | 1794.2 ± 141.3 | |
5-HIAA/5-HT | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 | |
[DA] | 6828.2 ± 1140.7 | 8175.8 ± 1676.7 | 9125.4 ± 673.7 | 7866.6 ± 1164.1 | |
[DOPAC] | 2164.2 ± 181.6 | 2021.4 ± 296.9 | 2545.4 ± 131.4 | 2394.0 ± 277.8 | |
[HVA] | 1450.0 ± 183.8 | 1486.8 ± 128.0 | 1666.5 ± 115.8 | 1686.2 ± 160.9 | |
DOPAC/DA | 0.4 ± 0.09 | 0.5 ± 0.2 | 0.3 ± 0.03 | 0.4 ± 0.05 | |
HVA/DA | 0.3 ± 0.1 | 0.2 ± 0.05 | 0.2 ± 0.02 | 0.2 ± 0.04 | |
Striatum | [5-HT] | 1216.3 ± 220.7 | 1360.6 ± 172.0 | 1473.2 ± 219.4 | 1267.2 ± 223.0 |
[5-HIAA] | 2616.5 ± 472.5 | 1972.9 ± 258.6 | 2850.3 ± 269.4* | 2484.1 ± 276.4* | |
5-HIAA/5-HT | 2.2 ± 0.3 | 1.7 ± 0.2 | 2.2 ± 0.3 | 2.6 ± 0.5 | |
[DA] | 19,358.3 ± 4421.4 | 10,115.5 ± 2406.4# | 18,595.6 ± 3641.0 | 13,783.9 ± 3034.9# | |
[DOPAC] | 3639.0 ± 541.3 | 3331.3 ± 633.5 | 3806.8 ± 393.6 | 3365.9 ± 629.9 | |
[HVA] | 2374.3 ± 500.1 | 2443.6 ± 366.1 | 2965.4 ± 291.9 | 2789.7 ± 307.4 | |
DOPAC/DA | 0.3 ± 0.05 | 0.5 ± 0.1 | 0.3 ± 0.08 | 0.3 ± 0.09 | |
HVA/DA | 0.1 ± 0.02 | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.04 | |