Fig. 9
CSF/serum quotient diagrams for IgG, IgM, and IgA (‘reibergrams’). Individual CSF/serum ratios of IgG, IgA, and IgM are plotted against CSF/serum albumin ratios. Values above the upper hyperbolic discrimination line, Qlim, indicate intrathecal synthesis of the respective immunoglobulin (Ig) class. Individual intrathecal fractions, IgIF, can be directly read by interpolation from the percentiles above Qlim (median values are given in Tables 3 and 4). Open circles represent samples from the ‘B/SC subgroup’; filled circles represent samples from the ‘PN/CN/H subgroup’. Graphs were created using CSF Research Tool v3.0 (CoMed GmbH, Soest, Germany). B/SC brain spinal cord, IgG/A/M immunoglobulin G/A/M, PN/CN/H peripheral nerve/cranial nerve/headache only, QIgG/A/M CSF/serum IgG/A/M ratios, QAlb CSF/serum albumin ratio