Table 3 Frequency of intrathecal IgG synthesis, oligoclonal IgG patterns, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum in group I

Intrathecal IgG synthesis

 OCB positive or IgG-IF ≥ 10%

Samples

2/103 (1.9%)

1/71 (1.4%)

0/21 (0%)

1/57 (1.8%)

0/13 (0%)

 OCB positive

Samples

2/103 (1.9%)

1/71 (1.4%)

0/21 (0%)

1/56 (1.8%)

0/12 (0%)

 OCB pattern 1

Samples

42/103 (40.8%)

33/71 (46.5%)

6/21 (28.6%)

23/56 (41.1%)

9/12 (75%)

 OCB pattern 2

Samples

0/103 (0%)

0/71 (0%)

0/21 (0%)

0/56 (0%)

0/12 (0%)

 OCB pattern 3

Samples

2/103 (1.9%)

1/71 (1.4%)

0/21 (0%)

1/56 (1.8%)

0/12 (0%)

 OCB pattern 4

Samples

58/103 (56.3%)

36/71 (50.7%)

15/21 (71.4%)

31/56 (55.4%)

3/12 (25%)

 OCB pattern 5

Samples

1/103 (1%)

1/71 (1.4%)

0/21 (0%)

1/56 (1.8%)

0/12 (0%)

 OCB pattern 2 or 3

Samples

2/103 (1.9%)

1/71 (1.4%)

0/21 (0%)

1/56 (1.8%)

0/12 (0%)

 OCB pattern 3 or 4

Samples

60/103 (58.3%)

37/71 (52.1%)

15/21 (71.4%)

32/56 (57.1%)

3/12 (25%)

 OCB pattern 1, 4, or 5

Samples

101/103 (98.1%)

70/71 (98.6%)

21/21 (100%)

32/56 (98.2%)

3/12 (100%)

 QIgG > Qlim(IgG)

Samples

1/115 (1%)

1/81 (1%)

0/21 (0%)

1/64 (1.6%)

0/16 (0%)

 QIgG, all LPs

–

3.7 (0.9–22.4;115)

3.8 (1–22.4;81)

4.1 (1.2–6.8;21)

3.85 (1.54–22.4;64)

3.7 (0.96–12.1;16)

 QIgG, if positive

–

8.3 (8.3–8.3;1)

8.3 (8.3–8.3;1)

n.a. (n.a.;0)

8.25 (8.25–8.25;1)

n.a. (n.a.;0)

 IgG-IF, all LPs

% IgG(CSF)

0 (0–32.2;115)

0 (0–32.2;81)

0 (0–0;21)

0 (0–32.2;64)

0 (0–0;16)

 IgG-IF, QIgG positives

% IgG(CSF)

32.2 (32.2–32.2;1)

32.2 (32.2–32.2;1)

n.a. (n.a.;0)

32.2 (32.2–32.2;1)

n.a. (n.a.;0)

 IgG-IF, > 10%

Samples

1/115 (0.9%)

1/81 (1.2%)

0/21 (0%)

1/64 (1.6%)

0/16 (0%)

 IgG-loc, all LPs

mg/l

0 (0–38;115)

0 (0–38;81)

0 (0–0;21)

0 (0–38;64)

n.a. (n.a.; 0)

 IgG-loc, QIgG positives

mg/l

38 (38–38;1)

38 (38–38;1)

n.a. (n.a.;0)

38 (38–38;1)

n.a. (n.a.;0)

 IgG CSF, all LPs

mg/l

40.4 (6.2–239;115)

41.7 (8–239;81)

40.4 (9.6–69;21)

43.75 (12–239;64)

34.95 (8–135;16)

 IgG CSF, QIgG positives

mg/l

118 (118–118;1)

118 (118–118;1)

n.a. (n.a.;0)

118 (118–118;1)

n.a. (n.a.;0)

 IgG serum, all LPs

g/l

11.3 (3.4–28.8;120)

11.3 (3.4–21.1;81)

10.7 (6.1–18.2;22)

11.45 (3.4–21.1;64)

11 (6.34–18.2;16)

 IgG serum, QIgG positives

g/l

14.3 (14.3–14.3;1)

14.3 (14.3–14.3;1)

n.a. (n.a.;0)

14.3 (14.3–14.3;1)

n.a. (n.a.;0)

 IgG serum, elevated

Samples

12/120 (10%)

5/81 (6.2%)

1/22 (4.5%)

4/64 (6.3%)

1/16 (6.3%)

 Link index, all

Samples

1/114 (1%)

1/80 (1%)

0/21 (0%)

1/63 (1.6%)

0/16 (0%)

 Link index, if positive

Index

1.1 (1.1–1.1;1)

1.1 (1.1–1.1;1)

n.a. (n.a.;0)

1.1 (1.1–1.1;1)

n.a. (n.a.;0)