Fig. 7

Immunostaining for β-amyloid in the cerebral cortex of 15-week-old SAMR1 mice (A) and 5-week-old (B) and 15-week-old (C, D) SAMP10 mice. D Section was stained for β-amyloid (green), CD31 (red) and DAPI (blue). It is worth noting that immunoreactivity of β-amyloid was observed in the perivascular space in the 15-week-old SAMP10 mice. Senile plaque was not observed. Scale bars: 10 μm. E Quantification of the immunostainings. Data are means ± SEs. They were analyzed by one-way ANOVA followed by the Bonferroni test (*p < 0.05). n = 4 for each group