Fig. 2

Minor impact of AM095 treatment on immune cell infiltration. Immune cell infiltration was assessed by counting the number of CD3⁺ (T-lymphocytes) and CD11b/c⁺ (myeloid cells) on sciatic nerve sections in randomly selected fields. a Representative images of immune cell infiltration at peak of disease at 14 dpi, and early remission phase at 21 dpi. b + c No significant difference was observed in the number of infiltrating CD3+ cells between peak of disease and remission phase (N = 9/8/4/4 from left to right). d + e While there was no significant reduction in CD3⁺ cells at 14 dpi, we recognized a slight decrease in myeloid cells under AM095 at 21 dpi (N = 5/5/5/6 from left to right)). Cell counts were normalized to area. Data represent mean ± s.e.m. P ≤ 0.05*. Scale bars indicate 50 µm