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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation

Fig. 3

Pharmacological microglia ablation (PLX5622) does not lead to changes in CSF/ventricular spaces in vivo. A Experimental timeline for PLX5622 mediated microglia ablation and MRI quantification. B T2-Weighted MRI shows no significant difference in control diet or PLX5622 diet mice before or after the diet treatment. C MRI image-based quantification of the ventricular volume in control and PLX5622 microglia ablated mice using serial coronal sections of T2-weighted MRI before and after 7 days of control of PLX5622 treatment. (n = 3 for each group, Mean ± SEM, and no statistical differences among any of the groups by two-way ANOVA with Tukey post-hoc analysis). Quantification result is from one cohort of mice with similar results observed from > 2 other independent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094