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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression

Fig. 6

IL-4 induces SNHG15 expression in macrophages through JAK-STAT6 signaling. A The JASPAR CORE database was used to search for potential interacting regions in the SNHG15 promoter. B Effects of STAT6 overexpression on SNHG15 expression in macrophages. C Effects of STAT6 knockdown on SNHG15 expression in macrophages. D The interaction of STAT6 with the SNHG15 promoter was determined by luciferase reporter assays. E The STAT6 binding sites in the SNHG15 promoter were further determined by luciferase reporter assays. F STAT6 occupancy in the SNHG15 promoter region was analyzed by ChIP. ** P < 0.01, *** P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094