Fig. 2
From: Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model
Sublethal CVB3 infection leads to ALS-related pathologies in vivo. A Representative images of viral protein VP1 immunohistochemical and H&E histological staining in the hippocampus regions of the brain from mock- and CVB3-infected C57BL/6J or SOD1G85R mice at day 10 PI. The red boxes indicate the region of the magnification. Black boxes on the top right illustrate the enlarged images. B Representative images of TDP-43 immunohistochemical staining in the hippocampus regions of the brain from mock- and CVB3-injected C57BL/6J or SOD1G85R mice at day 10 PI or week 60 PI (or humane endpoint) as indicated. The red arrows indicate TDP-43 mislocalization. Black boxes on the top right illustrate the enlarged images. Scale bar of magnified images = 100 μm. Scale bar of whole brain images = 1000 μm