Fig. 1

Cytokines: a Interleukin (IL)-6, b IL-8, c TNFα and d IL-10 responses in Paediatric Traumatic brain injury. Serum of children with mild TBI (mTBI) at the time of presentation and at 2 weeks as well as children with severe TBI (sTBI) at baseline and in response to LPS. Values expressed as pg/ml. Samples size (Vehicle: n = 104 controls, n = 98 mTBI at 0-4d, n = 29 mTBI at 10-14d, n = 6 severe TBI. LPS: n = 11 controls, n = 18 mTBI at 0-4d, n = 9 mTBI at 10-14d, n = 4 severe). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, patient cohort compared to controls. # = p < 0.05 response to LPS from baseline. a **p = 0.005 mTBI 0-4d compared to controls, ****p < 0.0001 control compared to sTBI at baseline, ##p = 0.001 controls pre and post LPS stimulation. #### p < 0.0001 mTBI 0-4d pre and post LPS. **p = 0.0015 controls compared to sTBI within LPS group. b ****p < 0.0001 mTBI 0 = 4d compared to controls, ****p < 0.0001 mTBI at 10-14d compared to controls, *p = 0.035 controls compared to sTBI in response to LPS. ^#p = 0.02 controls pre and post LPS, ^#p = 0.02 sTBI pre and post LPS ^####p < 0.0001 mTBI pre and post LPS ^####p < 0.0001 mTBI at 10-14d pre and post LPS. c ****p < 0.0001 mTBI 0 = 4d compared to controls, ****p < 0.0001 mTBI at 10-14d compared to controls ^##p = 0.009 sTBI pre and post LPS ^###p = 0.0001 mTBI at 10-14d pre and post LPS ^####p < 0.0001 mTBI pre and post LPS, LPS ^####p < 0.0001 controls pre and post LPS. d ****p < 0.0001 mTBI 0-4d compared to controls, ***p = 0.0004 mTBI at 10-14d compared to controls, *p = 0.037 controls compared to sTBI within LPS group