Fig. 2

Cytokines: a Interleukin 2 (IL)-2, b IL-4, c IFNγ and d IL-17A responses in Paediatric Traumatic brain injury. Serum of children with mild TBI (mTBI) at the time of presentation and at 2 weeks as well as children with severe TBI (sTBI) at baseline and, in response to LPS. Values were expressed as pg/ml. Samples size (Vehicle: n = 104 controls, n = 98 mTBI at 0-4d, n = 29 mTBI at 10-14d, n = 6 severe TBI. LPS: n = 11 controls, n = 18 mTBI at 0-4d, n = 9 mTBI at 10-14d, n = 4 severe). *p ≤ 0.05*, **p < 0.01, ***p < 0.001, ****p < 0.0001, patient cohort compared to controls. # = p < 0.05 response to LPS from baseline. a, b there was no statistical difference between groups. c ****p < 0.0001 mTBI at baseline compared to controls, **p = 0.0053 mTBI at 10-14d compared to controls, *p = 0.01 severe compared to controls d **p = 0.0097 control compared to mTBI at 10-14d, ****p < 0.0001 control compared to mTBI at 0-4d, ^##p = 0.0048 sTBI pre and post LPS stimulation