Fig. 3

Plasma and CSF soluble markers of immune activation. Transient increases in soluble markers of immune activation were observed in the plasma (interleukin, IL-15, monocyte chemoattractant protein-1, MCP-1, IL-1 receptor antagonist, IL-1RA and IL-2) and CSF (IL-15, MCP-1, granulocyte colony stimulating factor, G-CSF) early post-ZIKV infection. Each color represents data from individual animals as listed in Fig. 1B. *P values for CSF comparisons were based on early post-inoculation (PI) results from all 8 animals (Late group, n = 4 at day 4 PI, squares and Early group, n = 4 at day 8 PI, circles)