Fig. 4

Effects of MT5-MMP deficiency and MG132 treatment on N-cadherin levels. Immunoblot analyses of full length (NCad FL) and 40 kDa N-cadherin (NCad 40 kDa) levels in control and MG132 conditions, treated or not with IL-1β, and their representative quantifications normalized with β-actin. Black bars represent control (untreated) conditions, grey bars IL-1β-treated conditions (10 ng/mL for 24 h), blue bars MG132-treated conditions (5 μM for 24 h), and grey bars with blue borders MG132 and IL-1β co-treated conditions. Values are the mean ± SEM of 4–12 independent cultures by genotype. Values are presented as % of the control ^#p < 0.05 between genotypes. ANOVA followed by post hoc Fisher’s LSD test. IB immunoblot, O.D. optical density, A.U. arbitrary units