Fig. 1

Intravenous administration of hAMSCs dose-dependently improves ICH-induced neurobehavioral deficits during the subacute phase. A A protocol of neurobehavioral tests to optimize the administration dose of hAMSCs for mice bearing intracranial hemorrhage (ICH). The mice were divided into five groups: high-dose hAMSC group (n = 24), low-dose hAMSC group (n = 11), hADSC group (n = 11), ICH group (n = 32), and sham group (n = 32). The mice were then subject to the following neurobehavioral tests at Day 29 and later: open space swimming test (B), water maze learning test (C), and passive avoidance learning test (D). Data are plotted in mean ± SEM. P values are based on Tukey–Kramer test. *P < 0.05 and **P < 0.01 compared with the ICH group