Fig. 10

Model of microglial VPS35’s function in Aβ pathology and AD development. a Schematic diagram of microglial VPS35 in DAM development at multiple steps by regulate membrane Aβ receptors. b Microglial VPS35 deficiency precipitates Aβ pathology and AD development, likely by impair DAM development and Aβ phagocytosis, inducing increased Aβ, glial activation and dystrophic neurites formation, and finally leading cognition decline