Fig. 2
Cigarette smoke (CS) cessation reverses hippocampal-dependent spatial but not working memory impairments. A Spontaneous alternation percentage in Y-maze (F(4,42) = 6.340, p = 0.0004; n = 7–11); B Y-maze arm entries (F(4,40) = 4.482, p = 0.0004); C correlation between arm entries and spontaneous alternation in Y-maze (r(43) = 0.0306, p = 0.250); D novel objection recognition (NOR) task preference index (F(4,33) = 4.829, p = 0.0035; n = 7–9); E total distance (cm) travelled in NOR (F(4,31) = 3.201, p = 0.0260; n = 7–9); F correlation between preference index and total distance (cm) in mice exposed to room air (sham), CS or CS cessation for either 3 days, 10 days or 33 days (r(34) = 0.0001, p = 0.953); G heatmaps illustrating familiar object (circle) and novel object (square) exploration in the NOR. Heatmaps were generated in Ethovision using the over-heatmap setting allowing comparison between the representative animals. Data are expressed as mean + SEM. *p < 0.05, **p < 0.01