Fig. 5
Cigarette smoke (CS)-induced bronchoalveolar lavage fluid (BALF) cellularity was partially reversed by ebselen treatment. Mice were exposed to CS or room air (sham) concomitant with ebselen treatment for 8 weeks. A Body weight percentage change (n = 12 per group). B Total number of cells (interaction between exposure and treatment: F(1,11) = 20.88, p = 0.0008) (C); macrophages (main effect of exposure: F(1,11) = 246.5, p < 0.0001) (D); neutrophils (interaction between exposure and treatment: F(1,11) = 19.57, p = 0.0001) (E); and lymphocytes (main effect of exposure: F(1,11) = 173.9, p < 0.0001) in BALF (n = 12 per group). F BALF protein carbonylation (r(20) = 0.0523, p = 0.306; n = 12 per group). Data are expressed as mean + SEM. *** p < 0.001, **** p < 0.0001