Fig. 6
Prophylactic ebselen treatment reverses hippocampal-dependent memory impairments. A Spontaneous alternation percentage in Y-maze (significant effect of exposure: F(1,23) = 22.60, p < 0.0001; significant effect of treatment: F(1,23) = 9.792, p = 0.0047; n = 7–11); B Y-maze arm entries (significant interaction between exposure and treatment: F(1,12) = 44.56, p < 0.0001); C correlation between arm entries and spontaneous alternation in Y-maze (r(37) = 0.074, p = 0.092); D novel objection recognition (NOR) task preference index (F(1,11) = 29.48, p = 0.0002 n = 12); E total distance (cm) travelled in NOR (F(1,10) = 12.26, p = 0.0057; n = 11); F correlation between preference index and total distance (cm) in mice exposed to room air (sham), smoke and/or vehicle or ebselen (r(41) = 0.022, p = 0.341); G heatmaps illustrating familiar object (circle) and novel object (square) exploration in the NOR. Heatmaps were generated in Ethovision using the over-heatmap setting allowing comparison between the representative animals. Data are expressed as mean + SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001