Fig. 3

Effects of irisin on long-term neurobehavioral outcomes after ICH. A Representative swim paths of Morris water maze during the learning and memory phases of the test. B, C Spatial learning was assessed by the escape latency of Morris water maze on days 21–25 after ICH. D Spatial memory was assessed by the time spent in the target quadrant on day 26 after ICH. E Average swim speed for mice in the Morris water maze. F Rotarod test on days 7, 14, and 21 post-ICH. *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham + vehicle group; ^#p < 0.05, ^##p < 0.01 vs. ICH + vehicle group; ^p < 0.05, ^^p < 0.01, ^^^p < 0.001 vs. NT. Error bars are represented as mean ± SD. n = 10 per group