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Table 1 Characteristics of participants according to quartiles of plasma sTREM2

From: Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study from CATIS

Characteristics * sTREM2, pg/mL p trend
 < 247.45 247.45–401.27 401.27–651.60  ≥ 651.60
No. of patients 822 820 822 821  
Demographic features      
 Age, y 57.0 (50.0–64.0) 60.0 (53.0–68.0) 62.0 (56.0–71.0) 68.0 (59.0–74.0)  < 0.001
 Male sex, n (%) 613 (74.6) 551 (67.2) 491 (59.7) 443 (54.0)  < 0.001
 Current cigarette smoking, n (%) 354 (43.1) 310 (37.8) 289 (35.2) 253 (30.8)  < 0.001
 Current alcohol drinking, n (%) 302 (36.7) 288 (35.1) 227 (27.6) 192 (23.4)  < 0.001
Clinical features      
 Time from onset to randomization, h 10.0 (5.00–24.0) 12.0 (5.0–24.0) 10.0 (4.0–24.0) 10.0 (4.0–24.0) 0.12
 Admission systolic BP, mm Hg 161.3 (152.0–178.7) 163.3 (152.0–178.7) 161.3 (152.0–176.0) 162.0 (152.0–178.7) 0.63
 Admission diastolic BP, mm Hg 98.7 (90.0–101.3) 98.7 (90.0–101.3) 98.7 (90.0–100.7) 94.7 (88.7–100.0)  < 0.001
 Triglyceride, mmol/L 1.4 (1.0–2.0) 1.6 (1.0–2.3) 1.5 (1.0–2.3) 1.5 (1.0–2.2) 0.78
 Total cholesterol, mmol/L 4.8 (4.2–5.5) 5.0 (4.3–5.7) 5.1 (4.3–5.7) 5.1 (4.4–5.8)  < 0.001
 LDL-cholesterol, mmol/L 2.8 (2.2–3.4) 2.9 (2.3–3.5) 2.9 (2.3–3.5) 2.9 (2.3–3.6) 0.009
 HDL-cholesterol, mmol/L 1.2 (1.0–1.5) 1.2 (1.0–1.5) 1.2 (1.0–1.5) 1.3 (1.0–1.6)  < 0.001
 Fasting plasma glucose, mmol/L 5.8 (5.1–7.2) 5.8 (5.1–7.4) 5.8 (5.2–7.2) 5.8 (5.0–7.1) 0.68
 Admission NIHSS score 4.0 (2.0–8.0) 4.0 (2.0–7.0) 4.0 (3.0–7.0) 5.0 (3.0–8.0) 0.01
 High-sensitivity C-reactive protein, mg/L 1.7 (0.6–4.1) 1.8 (0.8–4.9) 1.9 (0.7–4.5) 2.3 (0.8–5.5) 0.38
Medical history, n (%)      
 Hypertension 658 (80.0) 648 (79.0) 643 (78.2) 633 (77.1) 0.13
 Hyperlipidemia 44 (5.4) 65 (7.9) 65 (7.9) 63 (7.7) 0.09
 Diabetes mellitus 140 (17.0) 158 (19.3) 148 (18.0) 136 (16.6) 0.66
 Coronary heart disease 58 ( 7.1) 66 ( 8.0) 97 (11.8) 117 (14.3)  < 0.001
 Family history of stroke, n (%) 185 (22.5) 163 (19.9) 135 (16.4) 132 (16.1)  < 0.001
Medication use history, n (%)      
 Antihypertensive medications 372 (45.3) 408 (49.8) 403 (49.0) 431 (52.5) 0.007
 Lipid-lowering medications 17 (2.1) 29 (3.5) 34 (4.1) 32 (3.9) 0.03
 Ischemic stroke subtype, n (%)      
  Thrombotic 644 (78.4) 648 (79.0) 628 (76.4) 599 (73.0) 0.004
  Embolic 18 (2.2) 38 (4.6) 35 (4.3) 65 (7.9)  < 0.001
  Lacunar 160 (19.5) 134 (16.3) 159 (19.3) 157 (19.1) 0.75
 Randomized treatment, n (%) 404 (49.1) 420 (51.2) 400 (48.7) 423 (51.5) 0.56
 Galectin-3, ng/ml 7.5 (5.2–10.1) 8.5 (5.9–11.3) 8.6 (6.3–11.8) 9.8 (6.5–13.9)  < 0.001
  1. sTREM2 soluble triggering receptor expressed on myeloid cells 2, BP blood pressure, LDL low-density lipoprotein, HDL high-density lipoprotein, NIHSS NIH Stroke Scale
  2. *Continuous variables are expressed as mean ± SD or median (interquartile range). Categorical variables are expressed as frequency (%)