|
NRI (Category free)
|
IDI
|
Likelihood ratio test, p value
|
Calibration statistic
|
---|
|
Estimate (95% CI), %
|
p value
|
Estimate (95% CI), %
|
p value
|
χ2
|
p value
|
---|
Age + NIHSS score
|
Reference
|
–
|
Reference
|
–
|
Reference
|
23.30
|
0.003
|
Age + NIHSS score + sTREM2 *
|
19.4 (7.8 to 30.9)
|
0.002
|
0.3 (0.1 to 0.6)
|
0.009
|
< 0.001
|
9.41
|
0.309
|
Basic model
|
Reference
| |
Reference
| |
Reference
|
9.29
|
0.318
|
Basic model + sTREM2 *
|
19.2 (7.6 to 30.8)
|
0.002
|
0.4 (0.1 to 0.7)
|
0.006
|
< 0.001
|
6.28
|
0.616
|
- sTREM2 soluble triggering receptor expressed on myeloid cells 2, NIHSS National Institute of Health Stroke Scale, NRI net reclassification index, IDI integrated discrimination improvement
- * Quartile Basic model included age, sex, time from onset to randomization, current smoking, alcohol drinking, admission NIHSS score, systolic blood pressure, high-sensitivity C-reactive protein, medical history (hypertension, hyperlipidemia, coronary heart disease and diabetes mellitus), medication use history (antihypertensive and lipid-lowering medications), family history of stroke, ischemic stroke subtype and randomized treatment