Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study from CATIS

Table 3 Performance of models with sTREM2 ^* to predict the primary outcome in patients with acute ischemic stroke

	NRI (Category free)		IDI		Likelihood ratio test, p value	Calibration statistic
	Estimate (95% CI), %	p value	Estimate (95% CI), %	p value	Likelihood ratio test, p value	χ²	p value
Age + NIHSS score	Reference	–	Reference	–	Reference	23.30	0.003
Age + NIHSS score + sTREM2 ^*	19.4 (7.8 to 30.9)	0.002	0.3 (0.1 to 0.6)	0.009	< 0.001	9.41	0.309
Basic model	Reference		Reference		Reference	9.29	0.318
Basic model + sTREM2 ^*	19.2 (7.6 to 30.8)	0.002	0.4 (0.1 to 0.7)	0.006	< 0.001	6.28	0.616

sTREM2 soluble triggering receptor expressed on myeloid cells 2, NIHSS National Institute of Health Stroke Scale, NRI net reclassification index, IDI integrated discrimination improvement
^* Quartile Basic model included age, sex, time from onset to randomization, current smoking, alcohol drinking, admission NIHSS score, systolic blood pressure, high-sensitivity C-reactive protein, medical history (hypertension, hyperlipidemia, coronary heart disease and diabetes mellitus), medication use history (antihypertensive and lipid-lowering medications), family history of stroke, ischemic stroke subtype and randomized treatment

ISSN: 1742-2094