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Table 3 Performance of models with sTREM2 * to predict the primary outcome in patients with acute ischemic stroke

From: Soluble TREM2 is associated with death and cardiovascular events after acute ischemic stroke: an observational study from CATIS

  NRI (Category free) IDI Likelihood ratio test, p value Calibration statistic
  Estimate (95% CI), % p value Estimate (95% CI), % p value χ2 p value
Age + NIHSS score Reference Reference Reference 23.30 0.003
Age + NIHSS score + sTREM2 * 19.4 (7.8 to 30.9) 0.002 0.3 (0.1 to 0.6) 0.009  < 0.001 9.41 0.309
Basic model Reference   Reference   Reference 9.29 0.318
Basic model + sTREM2 * 19.2 (7.6 to 30.8) 0.002 0.4 (0.1 to 0.7) 0.006  < 0.001 6.28 0.616
  1. sTREM2 soluble triggering receptor expressed on myeloid cells 2, NIHSS National Institute of Health Stroke Scale, NRI net reclassification index, IDI integrated discrimination improvement
  2. * Quartile Basic model included age, sex, time from onset to randomization, current smoking, alcohol drinking, admission NIHSS score, systolic blood pressure, high-sensitivity C-reactive protein, medical history (hypertension, hyperlipidemia, coronary heart disease and diabetes mellitus), medication use history (antihypertensive and lipid-lowering medications), family history of stroke, ischemic stroke subtype and randomized treatment