Fig. 2
From: The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Microglia have distinct morphologies in GFAP-IL6 versus GFAP-IFN mice. a-b Representative three-dimensional reconstructions of Iba1+ microglia from the cerebellum (a) and cortex (b) of 1- and 6-month-old WT, GFAP-IL6 and GFAP-IFN mice. c-d Imaris automated quantification of the total process length, branching points, terminal points and total Sholl intersections of cerebellar (c) and cortical (d) microglia. n = 2–3 mice/group, n = 15–31 cells/genotype. Graphs show individual values per cell and mean ± SEM. *, p < 0.05 compared with WT of the same age; ^, p < 0.05 compared with GFAP-IL6 of the same age; #, p < 0.05 compared with 1-month-old of the same genotype; x, p < 0.05 compared with 3-month-old of the same genotype using two-way ANOVA with Tukey’s post-test