Fig. 4
From: The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes
Microglia in GFAP-IL6 versus GFAP-IFN mice acquire unique transcriptional programs in addition to a common set of core response genes. a Two-way fold-change plot of differentially expressed genes in GFAP-IL6 versus WT microglia and GFAP-IFN versus WT microglia to identify core response genes (pink), as well as IL-6-skewed (orange) and IFN-α-skewed (blue) genes. b Enrichment map of top 100 significantly enriched GO biological processes by WebGestalt generated from the DEGs that are commonly upregulated by IL-6 and IFN-α. c Enrichment map of top 100 significantly enriched GO biological processes by WebGestalt generated from the DEGs that are upregulated and IL-6-skewed. d Enrichment map of top 100 enriched GO biological processes by WebGestalt generated from the DEGs that are upregulated and IFN-α-skewed. For b–d, nodes in enrichment maps are significantly enriched in GO lists (FDR < 0.05) and were used to name clusters