Fig. 4

Expression of brain homogenate of inflammatory mediators TNF-α, IL-6, HMGB1, MCP-1, MAPK-1, A20 and SOCS1 mRNA’s, illustrated in deltaCts. Group size of control groups varies from n = 5 to 6, groups size of infected groups varies from n = 9 to 10. Parametric two-way ANOVA (factors: genetics and time-point) were conducted and continuous variables were tested with post hoc Student’s t-tests for HMGB1 and A20. Data represent mean ± SD. Non-parametric two-way ANOVA was conducted and continuous variables were tested with post hoc Mann–Whitney U tests for TNF-α, IL-6, MCP-1, MAPK-1 and SOCS1. For non-parametric ANOVAs, the ranked transformation of data was performed. Data represent median ± IQR. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001